Description
Tissue Transglutamase IgA+IgG
Sample Type: Serum
Tests Included:
Tissue Transglutaminase (tTG) antibodies IgA and IgG measurement
Sample Required:
Blood sample
Test Time:
Results are typically available within a few days.
Test Range Values:
Normal values for tTG antibodies vary based on the laboratory and testing method used.
What is the test?
This test measures the presence and levels of Tissue Transglutaminase antibodies (tTG antibodies) of both IgA and IgG types. Elevated levels of these antibodies can indicate Celiac disease, an autoimmune disorder triggered by the ingestion of gluten.
Test Procedure:
A blood sample is drawn from a vein, and the presence and quantity of tTG antibodies (both IgA and IgG) are measured in the laboratory.
When to take the test:
When a healthcare provider suspects Celiac disease based on symptoms such as chronic diarrhea, abdominal pain, and weight loss, they may order this test.
Who should take the test:
Individuals with symptoms suggesting gluten intolerance or Celiac disease, especially if other initial tests like serological tests for IgA deficiency are inconclusive, may require this test.
Precautions for exceptional cases (pregnancy, etc.):
Tissue Transglutaminase testing is not specifically affected by pregnancy, but healthcare providers should always be informed about pregnancy status for accurate interpretation of results.
Frequently Asked Questions (FAQs) for Tissue Transglutaminase IgA+IgG Test:
Q1: Can tTG antibodies levels vary over time?
A: Yes, tTG antibody levels can fluctuate, and they may increase during periods of active Celiac disease. However, the levels can decrease with a gluten-free diet. Monitoring tTG antibody levels helps assess disease activity and dietary adherence.
Q2: Can a tTG test diagnose Celiac disease conclusively?
A: While elevated tTG antibody levels are indicative of Celiac disease, a definitive diagnosis usually involves confirmatory procedures such as an intestinal biopsy. The healthcare provider considers multiple factors for diagnosis.
Q3: Is a gluten-containing diet necessary before the tTG test?
A: Yes, for accurate results, individuals need to be on a gluten-containing diet before the test. A gluten-free diet may lead to false-negative results.
*Please note that specific testing protocols and guidelines may vary based on the latest recommendations from health authorities and regulatory agencies. It is essential to consult healthcare professionals and follow local testing guidelines for accurate and appropriate testing.
