Description
Factor V Leiden Mutation (1691 G>A)
Sample Type:2Whole Blood
Tests Included:
Detection of Factor V Leiden genetic mutation associated with an increased risk of blood clots.
Sample Required:
Blood sample for genetic analysis.
Test Time:
Results are typically available within a few days to a week.
Test Range Values:
Presence or absence of Factor V Leiden mutation.
What is the test?
Factor V Leiden PCR detects a specific genetic mutation (G1691A) in the Factor V gene. This mutation increases the risk of abnormal blood clot formation, leading to conditions such as deep vein thrombosis (DVT) and pulmonary embolism (PE). Factor V Leiden mutation is a common hereditary cause of thrombophilia.
Test Procedure:
A blood sample is collected from the patient. Genetic analysis using PCR is performed to detect the presence of the Factor V Leiden mutation.
When to take the test:
The test is recommended for individuals with a personal or family history of blood clots, especially at a young age or without obvious risk factors. It is also indicated for individuals with recurrent miscarriages or unexplained thrombotic events.
Who should take the test:
Individuals with suspected or confirmed thrombophilia, those with a family history of Factor V Leiden mutation, or those requiring genetic evaluation for thrombotic risk undergo Factor V Leiden PCR testing.
Precautions for exceptional cases (pregnancy, etc.):
Genetic testing for Factor V Leiden mutation does not involve significant risks and is generally safe for pregnant individuals. However, it is essential to consult a healthcare provider or genetic counselor for personalized guidance.
Frequently Asked Questions (FAQs) for Factor V Leiden PCR Test:
Q1: Is Factor V Leiden mutation treatable?
A: Factor V Leiden mutation itself is not treatable, as it is a genetic condition. However, individuals with this mutation and a history of blood clots may receive anticoagulant medications, such as blood thinners, to reduce the risk of clot formation. Treatment decisions are made based on individual medical history and risk factors.
Q2: Can Factor V Leiden mutation affect pregnancy?
A: Yes, Factor V Leiden mutation can increase the risk of pregnancy complications, including miscarriage and deep vein thrombosis during pregnancy. Pregnant individuals with a known Factor V Leiden mutation may require special monitoring and, in some cases, blood-thinning medications to reduce the risk of complications.
Q3: Is Factor V Leiden mutation common?
A: Factor V Leiden mutation is one of the most common genetic mutations associated with thrombophilia. Those of European ancestry are more likely to experience it. Having one copy of the mutation (heterozygous) increases the risk of blood clots, while having two copies (homozygous) further elevates the risk. Genetic testing helps identify carriers of the mutation.
*Please note that specific testing protocols and guidelines may vary based on the latest recommendations from health authorities and regulatory agencies. It is essential to consult healthcare professionals and follow local testing guidelines for accurate and appropriate testing.
