Description
Glutamate Receptors(TYPE NMDA),Glutamate Receptors(Type AMPA1 & AMPA2,Glur1/Glur2) Contactin Associated Protein 2(CASPR2) Dipeptidyl Aminopeptidase Like Protein 6 (DPPX) Leucine Rich Glioma, Inactivated Protein (LGI1) Gaba
Receptors (GABARB1/B2)
Sample Type: Cerebral Spinal Fluid / Serum
Tests Included:
Immunofluorescence assay to detect antibodies associated with autoimmune encephalitis.
Sample Required:
Blood sample or cerebrospinal fluid (CSF).
Test Time:
Results may take several days to weeks, depending on the specific antibodies being tested and the laboratory’s protocols.
Test Range Values:
Results are typically reported as positive or negative for specific antibodies associated with autoimmune encephalitis.
What is the test?
The Indirect Immunofluorescence Test (IIFT) is used to detect antibodies directed against neuronal cell surface or synaptic proteins associated with autoimmune encephalitis, an inflammatory condition affecting the brain.
Test Procedure:
A blood sample or cerebrospinal fluid is collected and tested in the laboratory for the presence of specific antibodies using immunofluorescence techniques.
When to take the test:
This test is ordered when there’s suspicion of autoimmune encephalitis based on symptoms like confusion, seizures, or abnormal behavior.
Who should take the test:
Individuals showing neurological symptoms suggestive of autoimmune encephalitis, as determined by a healthcare provider, may be recommended to undergo this test.
Precautions for exceptional cases (if any):
Specific antibodies may require distinct handling or preparation of samples. The healthcare provider will provide guidance on any special considerations.
Frequently Asked Questions (FAQs) for Autoimmune Encephalitis By IIFT:
Q1: What antibodies are typically tested for in autoimmune encephalitis?
A: Common antibodies tested include NMDA receptor antibodies, LGI1 antibodies, CASPR2 antibodies, among others, associated with different types of autoimmune encephalitis.
Q2: Is this test definitive in diagnosing autoimmune encephalitis?
A: A positive result indicates the presence of specific antibodies associated with the condition, but clinical correlation and additional tests may be necessary for a complete diagnosis.
Q3: Can this test differentiate between different types of autoimmune encephalitis?
A: Yes, the specific antibodies detected can help identify different subtypes of autoimmune encephalitis, guiding targeted treatment approaches.
Q4: Can other conditions mimic autoimmune encephalitis?
A: Yes, other conditions like infections or metabolic disorders can present with similar neurological symptoms, so diagnosis requires a comprehensive evaluation.
Q5: Can the test results change over time?
A: Antibody levels might fluctuate, and additional testing might be needed if symptoms persist or new symptoms develop to monitor changes in antibody levels.
*Please note that specific testing protocols and guidelines may vary based on the latest recommendations from health authorities and regulatory agencies. It is essential to consult healthcare professionals and follow local testing guidelines for accurate and appropriate testing.
