Description
HLA-B*27
Sample Type:2Whole Blood
Tests Included:
Detection of HLA-B27 antigen, a genetic marker associated with certain autoimmune diseases, including ankylosing spondylitis and reactive arthritis.
Sample Required:
Blood sample for HLA-B27 antigen analysis.
Test Time:
Results are typically available within a few days to a week.
Test Range Values:
Presence or absence of HLA-B27 antigen.
What is the test?
HLA-B27 Direct Testing identifies the presence of HLA-B27 antigen on the surface of white blood cells. This antigen is associated with an increased risk of autoimmune diseases, particularly ankylosing spondylitis and reactive arthritis. HLA-B27 testing aids in the diagnosis and assessment of these conditions.
Test Procedure:
A blood sample is collected from the patient. Laboratory analysis is performed to detect the presence of HLA-B27 antigen using specific techniques.
When to take the test:
The test is recommended for individuals with symptoms suggestive of ankylosing spondylitis, reactive arthritis, or related autoimmune conditions. It is especially useful when assessing individuals with a family history of these diseases.
Who should take the test:
Individuals with suspected autoimmune diseases, particularly ankylosing spondylitis and reactive arthritis, those with a family history of these conditions, or those requiring further evaluation for autoimmune disease risk undergo HLA-B27 Direct Testing.
Precautions for exceptional cases (pregnancy, etc.):
HLA-B27 testing is generally safe for pregnant individuals. However, it is essential to consult a healthcare provider for personalized guidance.
Frequently Asked Questions (FAQs) for HLA-B27 Direct Testing:
Q1: Can HLA-B27 testing diagnose ankylosing spondylitis or reactive arthritis definitively?
A: HLA-B27 testing is not a definitive diagnostic test for ankylosing spondylitis or reactive arthritis. The presence of HLA-B27 antigen increases the risk of these conditions but does not confirm the diagnosis. Clinical evaluation, imaging studies, and other tests are necessary for a comprehensive diagnosis.
Q2: What other conditions are associated with HLA-B27 positivity?
A: In addition to ankylosing spondylitis and reactive arthritis, HLA-B27 positivity is associated with other autoimmune conditions such as uveitis (inflammation of the eye), psoriatic arthritis, and certain forms of inflammatory bowel disease. However, the presence of HLA-B27 alone does not indicate a specific disease and requires clinical correlation.
Q3: Is HLA-B27 testing routinely performed in autoimmune disease evaluations?
A: HLA-B27 testing is often included as part of the autoimmune disease evaluation, especially when ankylosing spondylitis, reactive arthritis, or related conditions are suspected. It helps healthcare providers assess the risk and guide further diagnostic investigations.
*Please note that specific testing protocols and guidelines may vary based on the latest recommendations from health authorities and regulatory agencies. It is essential to consult healthcare professionals and follow local testing guidelines for accurate and appropriate testing.
