Description
HLA-DQ2/DQ8
Sample Type:2Whole Blood
Tests Included:
Detection of HLA-DQ2 and HLA-DQ8 genetic markers associated with celiac disease.
Sample Required:
Blood sample for genetic analysis.
Test Time:
Results are typically available within a few days to a week.
Test Range Values:
Presence or absence of HLA-DQ2 and HLA-DQ8 alleles.
What is the test?
HLA-DQ2/DQ8 genetic testing identifies specific genetic markers (alleles) associated with celiac disease, an autoimmune disorder triggered by the ingestion of gluten. Individuals with certain HLA-DQ2 or HLA-DQ8 alleles are at an increased risk of developing celiac disease.
Test Procedure:
A blood sample is collected from the patient. Genetic analysis is performed to detect the presence of HLA-DQ2 and HLA-DQ8 alleles associated with celiac disease susceptibility.
When to take the test:
The test is recommended for individuals with symptoms suggestive of celiac disease, especially if other tests, such as serological tests or biopsies, are inconclusive. It is also used for family members of individuals diagnosed with celiac disease to assess the risk.
Who should take the test:
Individuals with suspected celiac disease, those with a family history of celiac disease, or those requiring further evaluation for celiac disease risk undergo HLA-DQ2/DQ8 genetic testing.
Precautions for exceptional cases (pregnancy, etc.):
Genetic testing for HLA-DQ2/DQ8 alleles does not involve significant risks and is generally safe for pregnant individuals. However, it is essential to consult a healthcare provider or genetic counselor for personalized guidance.
Frequently Asked Questions (FAQs) for HLA-DQ2/DQ8 Genetic Testing:
Q1: Can HLA-DQ2/DQ8 genetic testing diagnose celiac disease?
A: HLA-DQ2/DQ8 genetic testing cannot diagnose celiac disease on its own. It can identify individuals at an increased risk of developing celiac disease due to specific genetic markers. For a definitive diagnosis, additional tests, such as serological tests (antibody tests) and intestinal biopsy, are required.
Q2: If I have HLA-DQ2 or HLA-DQ8 alleles, does it mean I will definitely develop celiac disease?
A: Having HLA-DQ2 or HLA-DQ8 alleles increases the risk of developing celiac disease but does not guarantee its onset. Many individuals with these genetic markers do not develop celiac disease. Genetic testing helps assess the risk, but the presence of these alleles alone is not sufficient for a celiac disease diagnosis.
Q3: Can HLA-DQ2/DQ8 genetic testing be used to monitor celiac disease progression or treatment effectiveness?
A: No, HLA-DQ2/DQ8 genetic testing is not used for monitoring disease progression or treatment effectiveness. It is primarily utilized for assessing the risk of developing celiac disease. Monitoring and management of celiac disease involve other tests, such as serological tests and clinical evaluations, to assess symptoms and dietary adherence.
*Please note that specific testing protocols and guidelines may vary based on the latest recommendations from health authorities and regulatory agencies. It is essential to consult healthcare professionals and follow local testing guidelines for accurate and appropriate testing.
