Description
Bacteria:
Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitides, Streptococcus agalactiae, Streptococcus pneumonia
Viruses:
Cytomegalovirus (CMV), Enterovirus (EV), Herpes simplex virus (HSV-1), Herpes simplex virus (HSV- 2), Human herpesvirus 6 (HHV-6), Human parechovirus (HpeV), Varicella zoster virus (VZV) Yeast:
Cryptococcus neoformans/gattii
0.2 mL of CSF (do not centrifuge)
Sample Type:0.2 mL of Cerebral Spinal Fluid (do not centrifuge)
Tests Included:
The ME Panel typically comprises various tests to diagnose and differentiate between meningitis and encephalitis, including cerebrospinal fluid (CSF) analysis, PCR (polymerase chain reaction) tests for specific viral or bacterial pathogens, and antibody tests.
Sample Required:
CSF sample (from a lumbar puncture) and sometimes blood sample.
Test Time:
Results might vary based on the tests performed, typically available within a few days to a week.
Test Range Values:
Interpretation is based on the presence or absence of specific pathogens, abnormalities in CSF components, or elevated antibody levels.
What is the test?
The ME Panel aims to diagnose infections or inflammatory conditions affecting the central nervous system (CNS), specifically distinguishing between meningitis (inflammation of meninges) and encephalitis (inflammation of the brain).
Test Procedure:
CSF and blood samples are collected and analyzed in the laboratory for pathogens, abnormalities in CSF components, or elevated antibody levels.
When to take the test:
It’s ordered when there’s suspected CNS infection or inflammation based on symptoms like severe headaches, fever, altered mental status, or neurological signs.
Who should take the test:
Individuals exhibiting symptoms suggestive of CNS infection or inflammation might require this panel to diagnose and differentiate between meningitis and encephalitis.
Precautions for exceptional cases (if any):
Lumbar puncture for CSF collection requires specific preparation and post-procedure care. Follow healthcare provider instructions.
Frequently Asked Questions (FAQs) for Meningitis/Encephalitis (ME) Panel:
Q1: What pathogens does the panel test for?
A: It typically tests for common bacterial (e.g., Streptococcus, Neisseria), viral (e.g., herpes simplex virus), and sometimes fungal pathogens causing CNS infections.
Q2: Is the lumbar puncture procedure painful?
A: It might cause discomfort, but local anesthesia is used to minimize pain during the procedure.
Q3: Can the panel definitively diagnose the cause of infection?
A: It provides crucial information about pathogens or abnormalities in CSF but may not always identify the specific cause.
Q4: Are there risks associated with a lumbar puncture?
A: Potential risks include headache, infection, or bleeding, but complications are rare.
Q5: Can encephalitis and meningitis have similar symptoms?
A: Yes, they can present with similar symptoms initially, but specific neurological signs might differ.
*Please note that specific testing protocols and guidelines may vary based on the latest recommendations from health authorities and regulatory agencies. It is essential to consult healthcare professionals and follow local testing guidelines for accurate and appropriate testing.
