Description
Serum, Sex hormone-binding globulin (SHBG) produced by the liver helps to transport biologically inactive forms of hormones such as testosterone, estradiol, and dihydrotestosterone into the bloodstream. Changes in its levels may have an effect on the amount of hormone available to the body. SHBG test is used for the evaluation of androgen deficiency or excess. Increased SHBG may be associated with liver disease, hyperthyroidism, hormone replacement therapy, oral contraceptives, and fertility issue. Deficiency is observed in metabolic syndrome, polycystic ovary syndrome, hypothyroidism, and Cushing syndrome., Non Fasting
Sample Required:
A blood sample is required for SHBG testing. This sample is typically collected from a vein in your arm.
Test Time:
Results for SHBG testing are usually available within a few days to a week, depending on the laboratory’s processing time.
Test Normal Range:
Normal reference ranges for SHBG can vary between labs, but they generally fall within 10 to 50 nanomoles per liter (nmol/L).
What is the Test:
Sex Hormone Binding Globulin (SHBG) is a protein produced by the liver that binds to certain hormones, including testosterone and estradiol (a form of estrogen). This test measures the concentration of SHBG in the blood.
Test Procedure:
A healthcare provider will collect a blood sample from a vein in your arm using a needle and a collection tube. A blood sample is delivered to a laboratory for testing. An automated analyzer in the laboratory detects the concentration of SHBG in the blood.
When to Take the Test:
SHBG testing is often ordered as part of hormone level assessments. It may be performed if there are concerns about hormonal imbalances, such as in cases of polycystic ovary syndrome (PCOS) or androgen excess.
Who Should Take This Test:
Individuals who may benefit from SHBG testing include those with suspected hormonal imbalances or those undergoing evaluation for conditions like PCOS.
Precautions for Exceptional Cases (Pregnancy, etc.):
SHBG testing is typically not affected by pregnancy or other exceptional cases. However, it’s essential to discuss any specific concerns with your healthcare provider.
FAQs (Frequently Asked Questions):
Q1: Why is SHBG testing important?
A: SHBG levels can impact the availability of sex hormones like testosterone and estrogen in the body. Understanding these levels can aid in diagnosing and managing hormonal conditions.
Q2: Can SHBG levels be altered by medications?
A: Yes, certain medications, such as birth control pills and steroids, can affect SHBG levels. Inform your doctor about any medications you’re taking.
Q3: What do high or low SHBG levels indicate?
A: High SHBG levels can result in lower levels of free (unbound) testosterone, while low SHBG levels can lead to higher levels of free testosterone. These imbalances can have various effects on the body.
Q4: Are there lifestyle changes that can influence SHBG levels?
A: Yes, factors like weight loss, regular exercise, and dietary choices can affect SHBG levels. Lifestyle modifications can be considered for managing hormonal imbalances.
Q5: Is SHBG testing used for diagnosing infertility?
A: SHBG testing can be part of fertility evaluations, especially when hormonal imbalances are suspected as a contributing factor to infertility. However, it is only one of several tests used in this context.
